[HTML][HTML] Exendin-(9–39) Corrects Fasting Hypoglycemia in SUR-1–/–Mice by Lowering cAMP in Pancreatic β-Cells and Inhibiting Insulin Secretion
DD De León, C Li, MI Delson, FM Matschinsky… - Journal of Biological …, 2008 - ASBMB
Congenital hyperinsulinism is a disorder of pancreatic β-cell function characterized by
failure to suppress insulin secretion in the setting of hypoglycemia, resulting in brain
damage or death if untreated. Loss-of-function mutations in the K ATP channel (composed of
two subunits: Kir6. 2 and SUR-1) are responsible for the most common and severe form of
congenital hyperinsulinism. Most patients are unresponsive to available medical therapy
and require palliative pancreatectomy. Similar to the human condition, the SUR-1–/–mouse …
failure to suppress insulin secretion in the setting of hypoglycemia, resulting in brain
damage or death if untreated. Loss-of-function mutations in the K ATP channel (composed of
two subunits: Kir6. 2 and SUR-1) are responsible for the most common and severe form of
congenital hyperinsulinism. Most patients are unresponsive to available medical therapy
and require palliative pancreatectomy. Similar to the human condition, the SUR-1–/–mouse …
