[HTML][HTML] Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA
SH Kim, NP Shanware, MJ Bowler… - Journal of Biological …, 2010 - ASBMB
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease that
preferentially targets motor neurons. It was recently found that dominant mutations in two
related RNA-binding proteins, TDP-43 (43-kDa TAR DNA-binding domain protein) and
FUS/TLS (fused in sarcoma/translated in liposarcoma) cause a subset of ALS. The
convergent ALS phenotypes associated with TDP-43 and FUS/TLS mutations are
suggestive of a functional relationship; however, whether or not TDP-43 and FUS/TLS …
preferentially targets motor neurons. It was recently found that dominant mutations in two
related RNA-binding proteins, TDP-43 (43-kDa TAR DNA-binding domain protein) and
FUS/TLS (fused in sarcoma/translated in liposarcoma) cause a subset of ALS. The
convergent ALS phenotypes associated with TDP-43 and FUS/TLS mutations are
suggestive of a functional relationship; however, whether or not TDP-43 and FUS/TLS …
