RNA processing pathways in amyotrophic lateral sclerosis
M Van Blitterswijk, JE Landers - neurogenetics, 2010 - Springer
neurogenetics, 2010•Springer
RNA processing is a tightly regulated, highly complex pathway which includes RNA
transcription, pre-mRNA splicing, editing, transportation, translation, and degradation of
RNA. Over the past few years, several RNA processing genes have been shown to be
mutated or genetically associated with amyotrophic lateral sclerosis (ALS), including the
RNA-binding proteins TDP-43 and FUS/TLS. These findings suggest that RNA processing
may represent a common pathogenic mechanism involved in development of ALS. In this …
transcription, pre-mRNA splicing, editing, transportation, translation, and degradation of
RNA. Over the past few years, several RNA processing genes have been shown to be
mutated or genetically associated with amyotrophic lateral sclerosis (ALS), including the
RNA-binding proteins TDP-43 and FUS/TLS. These findings suggest that RNA processing
may represent a common pathogenic mechanism involved in development of ALS. In this …
Abstract
RNA processing is a tightly regulated, highly complex pathway which includes RNA transcription, pre-mRNA splicing, editing, transportation, translation, and degradation of RNA. Over the past few years, several RNA processing genes have been shown to be mutated or genetically associated with amyotrophic lateral sclerosis (ALS), including the RNA-binding proteins TDP-43 and FUS/TLS. These findings suggest that RNA processing may represent a common pathogenic mechanism involved in development of ALS. In this review, we will discuss six ALS-related, RNA processing genes including their discovery, function, and commonalities.
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