Association of increased immunostaining for inducible nitric oxide synthase and nitrotyrosine with fibroblast growth factor transformation in pancreatic cancer
SM Vickers, LA MacMillan-Crow, M Green… - Archives of …, 1999 - jamanetwork.com
Background Despite recognition of the devastating malignant potential of pancreatic cancer,
the exact pathophysiological events contributing to tumor growth, vascular invasiveness,
and hepatic metastasis remain to be elucidated. Methods Twelve human pancreatic
adenocarcinomas were evaluated using immunohistochemical and in situ hybridization
techniques for the appearance of the angiogenic and neurogenic growth factors, acidic
fibroblast (FGF-1) and basic fibroblast growth factor (FGF-2), and their high-affinity receptors …
the exact pathophysiological events contributing to tumor growth, vascular invasiveness,
and hepatic metastasis remain to be elucidated. Methods Twelve human pancreatic
adenocarcinomas were evaluated using immunohistochemical and in situ hybridization
techniques for the appearance of the angiogenic and neurogenic growth factors, acidic
fibroblast (FGF-1) and basic fibroblast growth factor (FGF-2), and their high-affinity receptors …
