IL5RA and TNFRSF6B gene variants are associated with sporadic IgA nephropathy
XQ Liu, AD Paterson, N He… - Journal of the …, 2008 - journals.lww.com
Familial clustering and genome-wide linkage scans strongly support a genetic susceptibility
to familial IgA nephropathy (IgAN), but genetic factors that predispose to sporadic IgAN are
unknown. A high-throughput single nucleotide polymorphism (SNP) association study was
conducted using a customized Illumina BeadChip in 732 white patients with biopsy-proven
IgAN and 503 control subjects from Canada, France, and Finland. Approximately 93% of
1536 SNPs on the array were tag SNPs from Phase I+ II of the HapMap with a minor allele …
to familial IgA nephropathy (IgAN), but genetic factors that predispose to sporadic IgAN are
unknown. A high-throughput single nucleotide polymorphism (SNP) association study was
conducted using a customized Illumina BeadChip in 732 white patients with biopsy-proven
IgAN and 503 control subjects from Canada, France, and Finland. Approximately 93% of
1536 SNPs on the array were tag SNPs from Phase I+ II of the HapMap with a minor allele …
