Development of nephritis but not sialadenitis in autoimmune‐prone BAFF transgenic mice lacking marginal zone B cells
CA Fletcher, APR Sutherland, JR Groom… - European journal of …, 2006 - Wiley Online Library
European journal of immunology, 2006•Wiley Online Library
B cell-activating factor belonging to the TNF family (BAFF, also termed BLyS, TALL-1, zTNF-
4, THANK, and TNFSF13b) has emerged as a cytokine critical for peripheral B cell survival
and maturation (reviewed in [1–4]). BAFF supports the survival of both splenic immature
transitional and mature B cells, and maturation beyond the immature transitional type 1 (T1)
stage is impaired in BAFF-deficient mice (BAFF–/–)[5–7]. In addition, BAFF supports T-
independent isotype switching from IgM to IgA [8, 9]. Mice overexpressing BAFF (BAFF Tg …
4, THANK, and TNFSF13b) has emerged as a cytokine critical for peripheral B cell survival
and maturation (reviewed in [1–4]). BAFF supports the survival of both splenic immature
transitional and mature B cells, and maturation beyond the immature transitional type 1 (T1)
stage is impaired in BAFF-deficient mice (BAFF–/–)[5–7]. In addition, BAFF supports T-
independent isotype switching from IgM to IgA [8, 9]. Mice overexpressing BAFF (BAFF Tg …
B cell-activating factor belonging to the TNF family (BAFF, also termed BLyS, TALL-1, zTNF-4, THANK, and TNFSF13b) has emerged as a cytokine critical for peripheral B cell survival and maturation (reviewed in [1–4]). BAFF supports the survival of both splenic immature transitional and mature B cells, and maturation beyond the immature transitional type 1 (T1) stage is impaired in BAFF-deficient mice (BAFF–/–)[5–7]. In addition, BAFF supports T-independent isotype switching from IgM to IgA [8, 9]. Mice overexpressing BAFF (BAFF Tg mice) develop autoimmune disorders similar
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