Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study)
A Lamine, A Caumont-Sarcos, ML Chaix… - Aids, 2007 - journals.lww.com
A Lamine, A Caumont-Sarcos, ML Chaix, A Saez-Cirion, C Rouzioux, JF Delfraissy…
Aids, 2007•journals.lww.comThe replicative potential of HIV-1 strains in a well-characterized group of eight HIV
controllers was investigated. Replication-competent viruses were detected in CD4 T-cell co-
culture supernatants from all HIV controllers. The phylogenetic analysis of C2V4 suggested
viral evolution or co-infection or superinfection in two out of the four patients analysed. The
vif and vpr genes were normal. Infection with HIV-1 variants with attenuated replicative
capacity cannot be a general factor accounting for undetectable viraemia in HIV controllers.
controllers was investigated. Replication-competent viruses were detected in CD4 T-cell co-
culture supernatants from all HIV controllers. The phylogenetic analysis of C2V4 suggested
viral evolution or co-infection or superinfection in two out of the four patients analysed. The
vif and vpr genes were normal. Infection with HIV-1 variants with attenuated replicative
capacity cannot be a general factor accounting for undetectable viraemia in HIV controllers.
Abstract
The replicative potential of HIV-1 strains in a well-characterized group of eight HIV controllers was investigated. Replication-competent viruses were detected in CD4 T-cell co-culture supernatants from all HIV controllers. The phylogenetic analysis of C2V4 suggested viral evolution or co-infection or superinfection in two out of the four patients analysed. The vif and vpr genes were normal. Infection with HIV-1 variants with attenuated replicative capacity cannot be a general factor accounting for undetectable viraemia in HIV controllers.
Lippincott Williams & Wilkins