The most basic function of the eukaryotic cell cycle is to duplicate accurately the vast amount
of DNA in the chromosomes and then segregate the copies into two daughter cells. These
cell cycle events are initiated sequentially at the appropriate times during the cell cycle by
successive activation of different types of complexes of cyclin and cyclin-dependent kinase
(Cdk). 1 The integrity of each cell cycle event is monitored by checkpoint mechanisms that
prevent initiation of the later event until the earlier event is complete (1). Chromosomes have …