Multiple functions of Jab1 are required for early embryonic development and growth potential in mice
K Tomoda, N Yoneda-Kato, A Fukumoto… - Journal of Biological …, 2004 - ASBMB
Jab1 interacts with a variety of signaling molecules and regulates their stability in
mammalian cells. As the fifth component of the COP9 signalosome (CSN) complex, Jab1
(CSN5) plays a central role in the deneddylation of the cullin subunit of the Skp1-Cullin-F
box protein ubiquitin ligase complex. In addition, a CSN-independent function of Jab1 is
suggested but is less well characterized. To elucidate the function of Jab1, we targeted the
Jab1 locus by homologous recombination in mouse embryonic stem cells. Jab1-null …
mammalian cells. As the fifth component of the COP9 signalosome (CSN) complex, Jab1
(CSN5) plays a central role in the deneddylation of the cullin subunit of the Skp1-Cullin-F
box protein ubiquitin ligase complex. In addition, a CSN-independent function of Jab1 is
suggested but is less well characterized. To elucidate the function of Jab1, we targeted the
Jab1 locus by homologous recombination in mouse embryonic stem cells. Jab1-null …
