[PDF][PDF] Thiol redox control via thioredoxin and glutaredoxin systems
A Holmgren, C Johansson, C Berndt… - Biochemical Society …, 2005 - researchgate.net
Biochemical Society Transactions, 2005•researchgate.net
Abstract The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox
potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive
oxygen species signals through thiol redox control mechanisms. Here, we give a brief
overview of the human Trx and Grx systems. The main part focuses on our current
knowledge about mitochondrial Grx2, which facilitates mitochondrial redox homoeostasis
during oxidative stress-induced apoptosis.
potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive
oxygen species signals through thiol redox control mechanisms. Here, we give a brief
overview of the human Trx and Grx systems. The main part focuses on our current
knowledge about mitochondrial Grx2, which facilitates mitochondrial redox homoeostasis
during oxidative stress-induced apoptosis.
Abstract
The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms. Here, we give a brief overview of the human Trx and Grx systems. The main part focuses on our current knowledge about mitochondrial Grx2, which facilitates mitochondrial redox homoeostasis during oxidative stress-induced apoptosis.
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