Thioredoxin (Trx) family members play critical roles in the regulation of cellular redox
homeostasis. Cancer cells exist in a stressed environment and rely on the Trxs for protection
against stress-disregulated redox signaling. The most extensively studied member of the
family is Trx-1 whose levels are increased in many human cancers most likely in direct
response to stress. Trx-1 contributes to many of the hallmarks of cancer including increased
proliferation, resistance to cell death and increased angiogenesis. Trx-1 is a validated …