Genetic evidence supports an early role for Notch signaling in the fate of podocytes during
glomerular development. Decreased expression of Notch transcriptional targets in
developing podocytes after the determination of cell fate suggests that constitutive Notch
signaling may oppose podocyte differentiation. This study determined the effects of
constitutive Notch signaling on podocyte differentiation by ectopically expressing Notch's
intracellular domain (NOTCH-IC), the biologically active, intracellular product of proteolytic …