Stabilization of atherosclerotic plaques: new mechanisms and clinical targets
P Libby, M Aikawa - Nature medicine, 2002 - nature.com
P Libby, M Aikawa
Nature medicine, 2002•nature.comResearch points to pivotal roles for lipids in the development of atherosclerotic plaques.
Lipid-lowering statins substantially reduce acute coronary events resulting from plaque
development, but only modestly reduce arterial stenosis. This apparent paradox has shifted
the goal of therapy towards plaque stabilization rather than enlargement of the lumen. More
thorough understanding of the biology of atherosclerosis should enable us to manipulate
plaque stability, and reduce further the acute complications of atherosclerosis.
Lipid-lowering statins substantially reduce acute coronary events resulting from plaque
development, but only modestly reduce arterial stenosis. This apparent paradox has shifted
the goal of therapy towards plaque stabilization rather than enlargement of the lumen. More
thorough understanding of the biology of atherosclerosis should enable us to manipulate
plaque stability, and reduce further the acute complications of atherosclerosis.
Research points to pivotal roles for lipids in the development of atherosclerotic plaques. Lipid-lowering statins substantially reduce acute coronary events resulting from plaque development, but only modestly reduce arterial stenosis. This apparent paradox has shifted the goal of therapy towards plaque stabilization rather than enlargement of the lumen. More thorough understanding of the biology of atherosclerosis should enable us to manipulate plaque stability, and reduce further the acute complications of atherosclerosis.
nature.com
