Vitamin E and retinopathy of prematurity: follow-up at one year
DB Schaffer, L Johnson, GE Quinn, M Weston… - Ophthalmology, 1985 - Elsevier
DB Schaffer, L Johnson, GE Quinn, M Weston, FW Bowen Jr
Ophthalmology, 1985•ElsevierFive hundred forty-five infants weighing less than 1501 g at birth were entered into a
randomized, prospective study to determine the effect of high serum levels (5 mg/dL) of
vitamin E used prophylactically to try to prevent or alter the natural course of retinopathy of
prematurity (ROP) and its sequel, retrolental fibroplasia (RLF). Three hundred twenty-eight
infants were available for the one-to two-year eye examination. Although there was a trend
(P= 0.072) toward less severe RLF among vitamin E-treated infants, the incidence of RLF …
randomized, prospective study to determine the effect of high serum levels (5 mg/dL) of
vitamin E used prophylactically to try to prevent or alter the natural course of retinopathy of
prematurity (ROP) and its sequel, retrolental fibroplasia (RLF). Three hundred twenty-eight
infants were available for the one-to two-year eye examination. Although there was a trend
(P= 0.072) toward less severe RLF among vitamin E-treated infants, the incidence of RLF …
Abstract
Five hundred forty-five infants weighing less than 1501 g at birth were entered into a randomized, prospective study to determine the effect of high serum levels (5 mg/dL) of vitamin E used prophylactically to try to prevent or alter the natural course of retinopathy of prematurity (ROP) and its sequel, retrolental fibroplasia (RLF). Three hundred twenty-eight infants were available for the one- to two-year eye examination. Although there was a trend (P = 0.072) toward less severe RLF among vitamin E-treated infants, the incidence of RLF was 11/162 (6.8%) in the placebo treated (P) infants, and 12/166 (7.2%) in the vitamin E-treated (E) infants. The incidences of hyperopia, myopia, anisometropia, strabismus and amblyopia were also similar in both the P and E groups.
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