Diverse human disorders are thought to arise from the misfolding and aggregation of an
underlying protein. Among them, prion diseases are some of the most intriguing disorders
that can be transmitted by an unprecedented infectious agent, termed prion, composed
mainly (if not exclusively) of the misfolded prion protein. The hallmark event in the disease is
the conversion of the native prion protein into the disease‐associated misfolded protein. We
have recently described a novel technology to mimic the prion conversion process in vitro …