A positive feedback loop between glycogen synthase kinase 3β and protein phosphatase 1 after stimulation of NR2B NMDA receptors in forebrain neurons
E Szatmari, A Habas, P Yang, JJ Zheng, T Hagg… - Journal of Biological …, 2005 - ASBMB
N-methyl-d-aspartate receptors (NMDARs) are critical for neuronal plasticity and survival,
whereas their excessive activation produces excitotoxicity and may accelerate
neurodegeneration. Here, we report that stimulation of NMDARs in cultured rat hippocampal
or cortical neurons and in the adult mouse brain in vivo disinhibited glycogen synthase
kinase 3β (GSK3β) by protein phosphatase 1 (PP1)-mediated dephosphorylation of GSK3β
at the serine 9 residue. NMDA-triggered GSK3β activation was mediated by NMDAR that …
whereas their excessive activation produces excitotoxicity and may accelerate
neurodegeneration. Here, we report that stimulation of NMDARs in cultured rat hippocampal
or cortical neurons and in the adult mouse brain in vivo disinhibited glycogen synthase
kinase 3β (GSK3β) by protein phosphatase 1 (PP1)-mediated dephosphorylation of GSK3β
at the serine 9 residue. NMDA-triggered GSK3β activation was mediated by NMDAR that …
