Potential mechanism for bradykinin-activated and inositol tetrakisphosphate-dependent Ca2+ influx by Ras and GAP1 in fibroblast cells
H Higashida, M Taketo, H Takahashi, S Yokoyama… - …, 1999 - Elsevier
Here we propose a molecular model for bradykinin receptor-operated and second
messenger (inositol-1, 3, 4, 5-tetrakisphosphate)-evoked Ca2+ influx and its potentiation by
oncogenic Ras, which is not store-depletion-induced, so-called capacitative, Ca2+ influx.
The principal idea for this hypothesis stems from observation that two bradykinin B2 receptor-
activated signal pathways, protein tyrosine phosphorylation and formation of inositol
tetrakisphosphate, merge during the Ca2+ influx process and that GTPase activating-protein …
messenger (inositol-1, 3, 4, 5-tetrakisphosphate)-evoked Ca2+ influx and its potentiation by
oncogenic Ras, which is not store-depletion-induced, so-called capacitative, Ca2+ influx.
The principal idea for this hypothesis stems from observation that two bradykinin B2 receptor-
activated signal pathways, protein tyrosine phosphorylation and formation of inositol
tetrakisphosphate, merge during the Ca2+ influx process and that GTPase activating-protein …
