GTP‐binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo
XR Bustelo, V Sauzeau, IM Berenjeno - Bioessays, 2007 - Wiley Online Library
XR Bustelo, V Sauzeau, IM Berenjeno
Bioessays, 2007•Wiley Online LibraryRho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although
originally implicated in the control of cytoskeletal events, it is currently known that these
GTPases coordinate diverse cellular functions, including cell polarity, vesicular trafficking,
the cell cycle and transcriptomal dynamics. In this review, we will provide an overview on the
recent advances in this field regarding the mechanism of regulation and signaling, and the
roles in vivo of this important GTPase family. BioEssays 29: 356–370, 2007.© 2007 Wiley …
originally implicated in the control of cytoskeletal events, it is currently known that these
GTPases coordinate diverse cellular functions, including cell polarity, vesicular trafficking,
the cell cycle and transcriptomal dynamics. In this review, we will provide an overview on the
recent advances in this field regarding the mechanism of regulation and signaling, and the
roles in vivo of this important GTPase family. BioEssays 29: 356–370, 2007.© 2007 Wiley …
Abstract
Rho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although originally implicated in the control of cytoskeletal events, it is currently known that these GTPases coordinate diverse cellular functions, including cell polarity, vesicular trafficking, the cell cycle and transcriptomal dynamics. In this review, we will provide an overview on the recent advances in this field regarding the mechanism of regulation and signaling, and the roles in vivo of this important GTPase family. BioEssays 29:356–370, 2007. © 2007 Wiley Periodicals, Inc.
Wiley Online Library