Targeting CAL as a negative regulator of ΔF508-CFTR cell-surface expression: an RNA interference and structure-based mutagenetic approach
M Wolde, A Fellows, J Cheng, A Kivenson… - Journal of Biological …, 2007 - ASBMB
PDZ domains are ubiquitous peptide-binding modules that mediate protein-protein
interactions in a wide variety of intracellular trafficking and localization processes. These
include the pathways that regulate the membrane trafficking and endocytic recycling of the
cystic fibrosis transmembrane conductance regulator (CFTR), an epithelial chloride channel
mutated in patients with cystic fibrosis. Correspondingly, a number of PDZ proteins have
now been identified that directly or indirectly interact with the C terminus of CFTR. One of …
interactions in a wide variety of intracellular trafficking and localization processes. These
include the pathways that regulate the membrane trafficking and endocytic recycling of the
cystic fibrosis transmembrane conductance regulator (CFTR), an epithelial chloride channel
mutated in patients with cystic fibrosis. Correspondingly, a number of PDZ proteins have
now been identified that directly or indirectly interact with the C terminus of CFTR. One of …
