[HTML][HTML] IL-11 up-regulates Tie-2 expression during the healing of gastric ulcers in rats
CY Wen, M Ito, H Wang, LD Chen, ZM Xu… - World Journal of …, 2003 - ncbi.nlm.nih.gov
CY Wen, M Ito, H Wang, LD Chen, ZM Xu, M Matsuu, K Shichijo, T Nakayama, M Nakashima…
World Journal of Gastroenterology: WJG, 2003•ncbi.nlm.nih.govAIM: To investigate Tie-2 expression during the repair of acetic acid-induced gastric ulcers in
rats treated with recombinant human IL-11 (rhIL-11) and in untreated control animals.
METHODS: Gastric ulcers were induced in male Wistar rats by applying acetic acid to the
fundus of the stomach. RhIL-11 (100 µg/kg twice daily, subcutaneously) was administered
from two days before ulcer induction and continued for five days after the induction. Control
rats received bovine serum albumin. Gastric specimens were collected at 3 and 5 d after the …
rats treated with recombinant human IL-11 (rhIL-11) and in untreated control animals.
METHODS: Gastric ulcers were induced in male Wistar rats by applying acetic acid to the
fundus of the stomach. RhIL-11 (100 µg/kg twice daily, subcutaneously) was administered
from two days before ulcer induction and continued for five days after the induction. Control
rats received bovine serum albumin. Gastric specimens were collected at 3 and 5 d after the …
Abstract
AIM: To investigate Tie-2 expression during the repair of acetic acid-induced gastric ulcers in rats treated with recombinant human IL-11 (rhIL-11) and in untreated control animals.
METHODS: Gastric ulcers were induced in male Wistar rats by applying acetic acid to the fundus of the stomach. RhIL-11 (100 µg/kg twice daily, subcutaneously) was administered from two days before ulcer induction and continued for five days after the induction. Control rats received bovine serum albumin. Gastric specimens were collected at 3 and 5 d after the induction of ulcer for immunohistochemical observation, Western blotting, and reverse transcription polymerase chain reaction (RT-PCR).
RESULTS: Immunohistochemical and Western blot analysis demonstrated that Tie-2 expression was enhanced in the rhIL-11-treated rats compared with the control animals at both intervals.
CONCLUSION: These findings suggested that IL-11 could accelerate ulcer healing, in part, by up-regulating Tie-2 expression and promoting angiogenesis.
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