Osteogenic protein-1 mRNA expression is selectively modulated after acute ischemic renal injury.
MM Almanzar, KS Frazier, PH Dube… - Journal of the …, 1998 - journals.lww.com
Abstract Osteogenic protein-1 (OP-1) is a morphogenetic factor highly expressed in the
kidney and involved in tissue repair and development. Homozygous OP-1-deficient mice die
shortly after birth due mainly to arrest of renal growth and differentiation. Because
postischemic injury involves several repair mechanisms, this study examined whether
kidney OP-1 mRNA expression is modulated after ischemia. Acute ischemic renal injury was
achieved in rats by unilateral clamping of the renal pedicle followed by reperfusion. Rats …
kidney and involved in tissue repair and development. Homozygous OP-1-deficient mice die
shortly after birth due mainly to arrest of renal growth and differentiation. Because
postischemic injury involves several repair mechanisms, this study examined whether
kidney OP-1 mRNA expression is modulated after ischemia. Acute ischemic renal injury was
achieved in rats by unilateral clamping of the renal pedicle followed by reperfusion. Rats …