[HTML][HTML] VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix

Z Poltorak, T Cohen, R Sivan, Y Kandelis… - Journal of Biological …, 1997 - ASBMB
A vascular endothelial growth factor (VEGF) mRNA species containing exons 1-6 and 8 of
the VEGF gene was found to be expressed as a major VEGF mRNA form in several cell lines
derived from carcinomas of the female reproductive system. This mRNA is predicted to
encode a VEGF form of 145 amino acids (VEGF 145). Recombinant VEGF 145 induced the
proliferation of vascular endothelial cells and promoted angiogenesis in vivo VEGF 145 was
compared with previously characterized VEGF species with respect to interaction with …