[HTML][HTML] KSHV-encoded viral IL-6 activates multiple human IL-6 signaling pathways
Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) encodes a structural and
functional homologue of human IL-6 called viral IL-6 (vIL-6). Expression of vIL-6 in KSHV-
related lymphoproliferative disorders has been implicated in their pathogenesis. vIL-6 has
been shown to mimic a number of IL-6 activities including stimulating the growth of IL-6
dependent cell lines and activating the JAK1 and STAT1/3 pathway in HepG2 cells.
However, IL-6 and vIL-6 display differences in receptor usage that may give rise to …
functional homologue of human IL-6 called viral IL-6 (vIL-6). Expression of vIL-6 in KSHV-
related lymphoproliferative disorders has been implicated in their pathogenesis. vIL-6 has
been shown to mimic a number of IL-6 activities including stimulating the growth of IL-6
dependent cell lines and activating the JAK1 and STAT1/3 pathway in HepG2 cells.
However, IL-6 and vIL-6 display differences in receptor usage that may give rise to …