Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma
P Attia, AV Maker, LR Haworth… - Journal of …, 2005 - journals.lww.com
Elimination of regulatory T lymphocytes may provide a way to break self-tolerance and
unleash the anti-tumor properties of circulating lymphocytes. The use of fusion proteins,
which link cytotoxic molecules to receptor targets, provides one approach to this problem.
This study examined the ability of a fusion protein of interleukin-2 (IL-2) and diphtheria toxin
(Denileukin Diftitox, DAB 389 IL-2, ONTAK) to eliminate regulatory T lymphocytes based on
their expression of high-affinity IL-2 receptors. Thirteen patients (12 with metastatic …
unleash the anti-tumor properties of circulating lymphocytes. The use of fusion proteins,
which link cytotoxic molecules to receptor targets, provides one approach to this problem.
This study examined the ability of a fusion protein of interleukin-2 (IL-2) and diphtheria toxin
(Denileukin Diftitox, DAB 389 IL-2, ONTAK) to eliminate regulatory T lymphocytes based on
their expression of high-affinity IL-2 receptors. Thirteen patients (12 with metastatic …