Immune suppression by tumor-specific CD4+ regulatory T-cells in cancer
RF Wang - Seminars in cancer biology, 2006 - Elsevier
RF Wang
Seminars in cancer biology, 2006•ElsevierRegulatory T-cells play essential roles in inducing self-tolerance by suppressing immune
responses against self such as autoantigens or non-self-antigens such as tumor and
pathogenic antigens. Recent studies demonstrate the existence of CD4+ regulatory T-cells
at tumor sites, implying that these Treg cells may induce antigen-specific and local immune
tolerance. This review will discuss the natural ligands and their potential roles of tumor-
specific CD4+ regulatory T-cells in cancer therapy.
responses against self such as autoantigens or non-self-antigens such as tumor and
pathogenic antigens. Recent studies demonstrate the existence of CD4+ regulatory T-cells
at tumor sites, implying that these Treg cells may induce antigen-specific and local immune
tolerance. This review will discuss the natural ligands and their potential roles of tumor-
specific CD4+ regulatory T-cells in cancer therapy.
Regulatory T-cells play essential roles in inducing self-tolerance by suppressing immune responses against self such as autoantigens or non-self-antigens such as tumor and pathogenic antigens. Recent studies demonstrate the existence of CD4+ regulatory T-cells at tumor sites, implying that these Treg cells may induce antigen-specific and local immune tolerance. This review will discuss the natural ligands and their potential roles of tumor-specific CD4+ regulatory T-cells in cancer therapy.
Elsevier