Knowing one's self: central tolerance revisited
J Sprent, CD Surh - Nature immunology, 2003 - nature.com
J Sprent, CD Surh
Nature immunology, 2003•nature.comTissue-specific antigens are expressed in the thymic medulla under the influence of the
AIRE gene, suggesting that unresponsiveness to these peripheral antigens is a result of
central tolerance. New data on T cell tolerance in AIRE−/− mice strongly support this
hypothsis.
AIRE gene, suggesting that unresponsiveness to these peripheral antigens is a result of
central tolerance. New data on T cell tolerance in AIRE−/− mice strongly support this
hypothsis.
Tissue-specific antigens are expressed in the thymic medulla under the influence of the AIRE gene, suggesting that unresponsiveness to these peripheral antigens is a result of central tolerance. New data on T cell tolerance in AIRE−/− mice strongly support this hypothsis.
nature.com