Fusion of a signal sequence to the interleukin-1β gene directs the protein from cytoplasmic accumulation to extracellular release
AG Wingren, O Björkdahl, T Labuda, L Björk… - Cellular …, 1996 - Elsevier
Interleukin (IL)-1 differs from most other cytokines by the lack of a signal sequence, which
results in the retention of the immature proform intracellularly (ic). Several cell types have the
capacity to produce IL-1, but release has been shown to be restricted predominantly to
monocytes/macrophages and associated with apoptosis of the producer cell. These features
have limited the studies on IL-1 in early T cell–APC interactions. To develop a model for
studying the biological effects of IL-1β release during long-lasting immune responses, we …
results in the retention of the immature proform intracellularly (ic). Several cell types have the
capacity to produce IL-1, but release has been shown to be restricted predominantly to
monocytes/macrophages and associated with apoptosis of the producer cell. These features
have limited the studies on IL-1 in early T cell–APC interactions. To develop a model for
studying the biological effects of IL-1β release during long-lasting immune responses, we …
