[HTML][HTML] Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP
Chondrocytes are influenced by mechanical forces to remodel cartilage extracellular matrix.
Previous studies have demonstrated the effects of mechanical forces on changes in
biosynthesis and mRNA levels of particular extracellular matrix molecules, and have
identified certain signaling pathways that may be involved. However, the broad extent and
kinetics of mechano-regulation of gene transcription has not been studied in depth. We
applied static compressive strains to bovine cartilage explants for periods between 1 and 24 …
Previous studies have demonstrated the effects of mechanical forces on changes in
biosynthesis and mRNA levels of particular extracellular matrix molecules, and have
identified certain signaling pathways that may be involved. However, the broad extent and
kinetics of mechano-regulation of gene transcription has not been studied in depth. We
applied static compressive strains to bovine cartilage explants for periods between 1 and 24 …
