A novel role for glucocorticoid-induced leucine zipper protein in epithelial sodium channel-mediated sodium transport
R Soundararajan, TT Zhang, J Wang… - Journal of Biological …, 2005 - ASBMB
The steroid hormone aldosterone stimulates sodium (Na+) transport in tight epithelia by
altering the expression of target genes that regulate the activity and trafficking of the
epithelial sodium channel (ENaC). We performed microarray analysis to identify aldosterone-
regulated transcripts in mammalian kidney epithelial cells (mpkC-CD c14). One target,
glucocorticoid-induced leucine zipper protein (GILZ), was previously identified by serial
analysis of gene expression (SAGE); however, its function in epithelial ion transport was …
altering the expression of target genes that regulate the activity and trafficking of the
epithelial sodium channel (ENaC). We performed microarray analysis to identify aldosterone-
regulated transcripts in mammalian kidney epithelial cells (mpkC-CD c14). One target,
glucocorticoid-induced leucine zipper protein (GILZ), was previously identified by serial
analysis of gene expression (SAGE); however, its function in epithelial ion transport was …
