Infectious mononucleosis: Epstein–Barr-Virus shedding in saliva and the oropharynx
JC Niederman, G Miller, HA Pearson… - … England Journal of …, 1976 - Mass Medical Soc
In an examination of excretion patterns of Epstein–Barr virus in 104 throat washings from 20
patients with infectious mononucleosis we found that three persons regularly shed virus from
the second week through the third month after onset; 15 demonstrated intermittent excretion
over three months, and in two cases, no virus was detected. In oral secretions, the virus
appeared to be located extracellularly. Transforming activity was demonstrated in aliquots
after centrifugation and filtration, in a sample in which cells were disrupted before filtration …
patients with infectious mononucleosis we found that three persons regularly shed virus from
the second week through the third month after onset; 15 demonstrated intermittent excretion
over three months, and in two cases, no virus was detected. In oral secretions, the virus
appeared to be located extracellularly. Transforming activity was demonstrated in aliquots
after centrifugation and filtration, in a sample in which cells were disrupted before filtration …
The transmission of infectious mononucleosis.
RJ Hoagland - American Journal of Medical Sciences, 1955 - cabdirect.org
The author, impressed by the prevalence of infectious mononucleosis among college
students and service personnel, and by its rarity in children and persons over the age of 40
years, suggests a new theory of transmission-namely intimate oral contact of such a nature
as to permit direct transfer of saliva. The failure of experimental transmission of the disease
to animals and volunteers suggested to him that the infectious agent, in sofar as the
pharyngeal secretions are concerned, may be destroyed or inhibited when diluted with …
students and service personnel, and by its rarity in children and persons over the age of 40
years, suggests a new theory of transmission-namely intimate oral contact of such a nature
as to permit direct transfer of saliva. The failure of experimental transmission of the disease
to animals and volunteers suggested to him that the infectious agent, in sofar as the
pharyngeal secretions are concerned, may be destroyed or inhibited when diluted with …
