Platelet physiology and thrombosis
RK Andrews, MC Berndt - Thrombosis research, 2004 - Elsevier
Glycoprotein (GP) Ibα of the GPIb-IX–V complex and GPVI bind von Willebrand factor (vWF)
and collagen, respectively, and are critical for the initial interaction of circulating platelets
with the injured vessel wall under high shear conditions. These interactions act together to
facilitate stable thrombus formation in vivo. Ligand binding to GPIb-IX–V of the leucine-rich
repeat family or GPVI of the immunoglobulin superfamily initiates platelet activation, and
inside–out activation of the platelet integrin, αIIbβ3, that binds vWF or fibrinogen and …
and collagen, respectively, and are critical for the initial interaction of circulating platelets
with the injured vessel wall under high shear conditions. These interactions act together to
facilitate stable thrombus formation in vivo. Ligand binding to GPIb-IX–V of the leucine-rich
repeat family or GPVI of the immunoglobulin superfamily initiates platelet activation, and
inside–out activation of the platelet integrin, αIIbβ3, that binds vWF or fibrinogen and …
