The roles of phosphatidylinositol 3-kinase and protein kinase Cζ for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine …
P Rojnuckarin, Y Miyakawa, NE Fox, J Deou… - Journal of Biological …, 2001 - ASBMB
Thrombopoietin (TPO) stimulates a network of intracellular signaling pathways that displays
extensive cross-talk. We have demonstrated previously that the ERK/mitogen-activated
protein kinase pathway is important for TPO-induced endomitosis in primary
megakaryocytes (MKs). One known pathway by which TPO induces ERK activation is
through the association of Shc with the penultimate phosphotyrosine within the TPO
receptor, Mpl. However, several investigators found that the membrane-proximal half of the …
extensive cross-talk. We have demonstrated previously that the ERK/mitogen-activated
protein kinase pathway is important for TPO-induced endomitosis in primary
megakaryocytes (MKs). One known pathway by which TPO induces ERK activation is
through the association of Shc with the penultimate phosphotyrosine within the TPO
receptor, Mpl. However, several investigators found that the membrane-proximal half of the …
