RSK2 activity is regulated by its interaction with PEA-15
H Vaidyanathan, JW Ramos - Journal of Biological Chemistry, 2003 - ASBMB
The ERK MAP (mitogen-activated protein) kinase cascade modulates many cellular
processes including transcription, adhesion, growth, survival, and proliferation. One target
substrate of ERK involved in regulating transcription is the p90 ribosomal S6 kinase (RSK)
isozyme, RSK2. Here we demonstrate that a small death effector domain-containing protein
called PEA-15 binds RSK2. RSK2 and PEA-15 (phosphoprotein enriched in astrocytes, 15
kDa) co-precipitated from cells and were colocalized in the cytoplasm. Furthermore, purified …
processes including transcription, adhesion, growth, survival, and proliferation. One target
substrate of ERK involved in regulating transcription is the p90 ribosomal S6 kinase (RSK)
isozyme, RSK2. Here we demonstrate that a small death effector domain-containing protein
called PEA-15 binds RSK2. RSK2 and PEA-15 (phosphoprotein enriched in astrocytes, 15
kDa) co-precipitated from cells and were colocalized in the cytoplasm. Furthermore, purified …