[HTML][HTML] Cathepsin S regulates the expression of cathepsin L and the turnover of γ-interferon-inducible lysosomal thiol reductase in B lymphocytes
K Honey, M Duff, C Beers, WH Brissette… - Journal of Biological …, 2001 - ASBMB
Loading of antigenic peptide fragments on major histocompatibility complex class II
molecules is essential for generation of CD4+ T cell responses and occurs after cathepsin-
mediated degradation of the invariant chain chaperone molecule. Cathepsins are expressed
differentially in antigen presenting cells, and mice deficient in cathepsin S or cathepsin L
exhibit severely impaired antigen presentation in peripheral lymphoid organs and the
thymus, respectively. To determine whether these defects are due solely to the block in …
molecules is essential for generation of CD4+ T cell responses and occurs after cathepsin-
mediated degradation of the invariant chain chaperone molecule. Cathepsins are expressed
differentially in antigen presenting cells, and mice deficient in cathepsin S or cathepsin L
exhibit severely impaired antigen presentation in peripheral lymphoid organs and the
thymus, respectively. To determine whether these defects are due solely to the block in …