A closer look at proteolysis and MHC-class-II-restricted antigen presentation
AM Lennon-Duménil, AH Bakker, P Wolf-Bryant… - Current opinion in …, 2002 - Elsevier
Current opinion in immunology, 2002•Elsevier
Antigen presentation by MHC class II molecules relies on the action of endocytic proteases,
which are differentially expressed in antigen-presenting cells and are regulated by different
components of the immune system. Endocytic enzymes process and convert exogenous
antigens into peptidic determinants capable of interaction with MHC class II molecules.
Chemical and genetic tools have recently been developed to study the role of lysosomal
proteases in antigen presentation.
which are differentially expressed in antigen-presenting cells and are regulated by different
components of the immune system. Endocytic enzymes process and convert exogenous
antigens into peptidic determinants capable of interaction with MHC class II molecules.
Chemical and genetic tools have recently been developed to study the role of lysosomal
proteases in antigen presentation.
Antigen presentation by MHC class II molecules relies on the action of endocytic proteases, which are differentially expressed in antigen-presenting cells and are regulated by different components of the immune system. Endocytic enzymes process and convert exogenous antigens into peptidic determinants capable of interaction with MHC class II molecules. Chemical and genetic tools have recently been developed to study the role of lysosomal proteases in antigen presentation.
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