[HTML][HTML] Stress pathway activation induces phosphorylation of retinoid X receptor
HY Lee, YA Suh, MJ Robinson, JL Clifford… - Journal of Biological …, 2000 - ASBMB
Cellular stresses inhibit retinoid signaling, but the molecular basis for this phenomenon has
not been revealed. Here, we present evidence that retinoid X receptor (RXR) is a substrate
for both mitogen-activated protein kinase kinase-4 (MKK4/SEK1) and its downstream
mediator c-Jun N-terminal kinase (JNK). MKK4/SEK1 and JNK recognized distinct features
on RXR in the DE and AB regions, respectively. Phosphorylation by MKK4/SEK1 had
profound effects on the biochemical properties of RXR, inhibiting the expression of genes …
not been revealed. Here, we present evidence that retinoid X receptor (RXR) is a substrate
for both mitogen-activated protein kinase kinase-4 (MKK4/SEK1) and its downstream
mediator c-Jun N-terminal kinase (JNK). MKK4/SEK1 and JNK recognized distinct features
on RXR in the DE and AB regions, respectively. Phosphorylation by MKK4/SEK1 had
profound effects on the biochemical properties of RXR, inhibiting the expression of genes …