[HTML][HTML] Role of TLR-2 in the activation of nuclear factor κB by oxidative stress in cardiac myocytes
S Frantz, RA Kelly, T Bourcier - Journal of Biological Chemistry, 2001 - ASBMB
Growing evidence from patients with heart failure and from experimental animal models
implicates effectors of innate immunity in the pathogenesis of this syndrome. The expression
of the innate immunity signaling protein, Toll-like receptor 4 (TLR4), is increased in cardiac
myocytes in situ and in failing myocardium, but the mechanism by which TLRs may be
activated in the failing heart remains unclear. We report that TLR2, which is expressed in
cardiac myocytes, participates in the response of these cells to oxidative stress, a major …
implicates effectors of innate immunity in the pathogenesis of this syndrome. The expression
of the innate immunity signaling protein, Toll-like receptor 4 (TLR4), is increased in cardiac
myocytes in situ and in failing myocardium, but the mechanism by which TLRs may be
activated in the failing heart remains unclear. We report that TLR2, which is expressed in
cardiac myocytes, participates in the response of these cells to oxidative stress, a major …