[HTML][HTML] Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-κB and JNK activation and apoptosis through distinct pathways
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the
TNF family that interacts with several receptors, including TRAIL-R1, TRAIL-R2, and TRAIL-
R4. TRAIL-R1 and TRAIL-R2 can induce apoptosis of cancer cells and activate the
transcription factor NF-κB. TRAIL-R4 can activate NF-κB and protect cells from TRAIL-
induced apoptosis. Here we show that TRAIL-R1-, TRAIL-R2-, and TRAIL-R4-induced NF-
κB activation are mediated by a TRAF2-NIK-IκB kinase α/β signaling cascade but is MEKK1 …
TNF family that interacts with several receptors, including TRAIL-R1, TRAIL-R2, and TRAIL-
R4. TRAIL-R1 and TRAIL-R2 can induce apoptosis of cancer cells and activate the
transcription factor NF-κB. TRAIL-R4 can activate NF-κB and protect cells from TRAIL-
induced apoptosis. Here we show that TRAIL-R1-, TRAIL-R2-, and TRAIL-R4-induced NF-
κB activation are mediated by a TRAF2-NIK-IκB kinase α/β signaling cascade but is MEKK1 …