The scavenger receptor class B type I (SR-BI), which is expressed in the liver and intestine,
plays a critical role in cholesterol metabolism in rodents. While hepatic SR-BI expression
controls high density lipoprotein (HDL) cholesterol metabolism, intestinal SR-BI has been
proposed to facilitate cholesterol absorption. To evaluate further the relevance of SR-BI in
the enterohepatic circulation of cholesterol and bile salts, we studied biliary lipid secretion,
hepatic sterol content and synthesis, bile acid metabolism, fecal neutral sterol excretion, and …