[HTML][HTML] Centripetal cholesterol flux to the liver is dictated by events in the peripheral organs and not by the plasma high density lipoprotein or apolipoprotein AI …
CD Jolley, LA Woollett, SD Turley, JM Dietschy - Journal of lipid research, 1998 - ASBMB
The major net flux of cholesterol in the intact animal or human is from the peripheral organs
to the liver. This flux is made up of cholesterol that is either synthesized in these peripheral
tissues or taken up as lipoprotein cholesterol. This study investigates whether it is the
concentration of apolipoprotein (apo) AI or high density lipoprotein in the plasma that
determines the magnitude of this flux or, alternatively, whether events within the peripheral
cells themselves regulate this important process. In mice that lack apoA-I and have very low …
to the liver. This flux is made up of cholesterol that is either synthesized in these peripheral
tissues or taken up as lipoprotein cholesterol. This study investigates whether it is the
concentration of apolipoprotein (apo) AI or high density lipoprotein in the plasma that
determines the magnitude of this flux or, alternatively, whether events within the peripheral
cells themselves regulate this important process. In mice that lack apoA-I and have very low …