Apolipoprotein AV (apoA-V), the newest member of the plasma apolipoprotein family, was
recently discovered by comparison of the mouse and human genomes. Studies in rodents
and population surveys of human apoA-V polymorphisms have noted a strong effect of apoA-
V on plasma triglyceride levels. Toward the elucidation of the biologic function of apoA-V, we
used spectroscopic and surface chemistry techniques to probe its structure and interfacial
activity. Computer-assisted sequence analysis of apoA-V predicts that it is very hydrophobic …