[HTML][HTML] Augmentation of ultraviolet B radiation-induced tumor necrosis factor production by the epidermal platelet-activating factor receptor
LC Dy, Y Pei, JB Travers - Journal of Biological Chemistry, 1999 - ASBMB
Ultraviolet B radiation (UVB) has been shown to damage human keratinocytes in part by
inducing oxidative stress and cytokine production. Indeed, UVB-induced production of the
pro-inflammatory and cytotoxic cytokine tumor necrosis factor α (TNF-α) has been implicated
in the epidermal damage seen in response to acute solar radiation. Though the lipid
mediator platelet-activating factor (PAF) is synthesized in response to oxidative stress, and
keratinocytes express PAF receptors linked to cytokine biosynthesis, it is not known whether …
inducing oxidative stress and cytokine production. Indeed, UVB-induced production of the
pro-inflammatory and cytotoxic cytokine tumor necrosis factor α (TNF-α) has been implicated
in the epidermal damage seen in response to acute solar radiation. Though the lipid
mediator platelet-activating factor (PAF) is synthesized in response to oxidative stress, and
keratinocytes express PAF receptors linked to cytokine biosynthesis, it is not known whether …