[HTML][HTML] Suppression of fatty acid synthase promoter by polyunsaturated fatty acids
Dietary polyunsaturated fat is known to suppress expression of fatty acid synthase (FAS), a
central enzyme in de novo lipogenesis. The sterol regulatory element-binding protein
(SREBP) has recently been shown to be involved in this suppression. We previously
reported that the first 2.1 kb of the FAS promoter are sufficient for transcriptional induction by
a high carbohydrate diet as well as suppression by polyunsaturated fat in transgenic mice.
Here, we first examined the DNA sequences responsible for SREBP-mediated suppression …
central enzyme in de novo lipogenesis. The sterol regulatory element-binding protein
(SREBP) has recently been shown to be involved in this suppression. We previously
reported that the first 2.1 kb of the FAS promoter are sufficient for transcriptional induction by
a high carbohydrate diet as well as suppression by polyunsaturated fat in transgenic mice.
Here, we first examined the DNA sequences responsible for SREBP-mediated suppression …