[HTML][HTML] Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes
AK Stoeckman, L Ma, HC Towle - Journal of Biological Chemistry, 2004 - ASBMB
The expression of genes encoding enzymes involved in de novo triglyceride synthesis
(lipogenesis) is transcriptionally induced in the liver in response to increased glucose
metabolism. The carbohydrate response element-binding protein (ChREBP) is a newly
identified basic helix-loop-helix/leucine zipper transcription factor proposed to regulate the
expression of the glucose-responsive gene pyruvate kinase. This gene contains a
carbohydrate response element (ChoRE) consisting of two E box motifs separated by 5 bp …
(lipogenesis) is transcriptionally induced in the liver in response to increased glucose
metabolism. The carbohydrate response element-binding protein (ChREBP) is a newly
identified basic helix-loop-helix/leucine zipper transcription factor proposed to regulate the
expression of the glucose-responsive gene pyruvate kinase. This gene contains a
carbohydrate response element (ChoRE) consisting of two E box motifs separated by 5 bp …