[HTML][HTML] RAG2 is down-regulated by cytoplasmic sequestration and ubiquitin-dependent degradation
R Mizuta, M Mizuta, S Araki, D Kitamura - Journal of Biological Chemistry, 2002 - ASBMB
Periodic accumulation and degradation of RAG2 (recombination-activating gene 2) protein
controls the cell-cycle-dependent V (D) J recombination of lymphocyte antigen receptor
genes. Here we show the molecular mechanism of RAG2 degradation. The RAG2 protein is
translocated from the nucleus to the cytoplasm and degraded through the
ubiquitin/proteasome system. RAG2 translocation is mediated by the Thr-490
phosphorylation of RAG2. Inhibition of this phosphorylation by p27Kip1 stabilizes the RAG2 …
controls the cell-cycle-dependent V (D) J recombination of lymphocyte antigen receptor
genes. Here we show the molecular mechanism of RAG2 degradation. The RAG2 protein is
translocated from the nucleus to the cytoplasm and degraded through the
ubiquitin/proteasome system. RAG2 translocation is mediated by the Thr-490
phosphorylation of RAG2. Inhibition of this phosphorylation by p27Kip1 stabilizes the RAG2 …