• Progressive electroencephalographic disorganization and decreased voltage amplitude in
the late components of the averaged visual evoked potentials were recorded in the last two
years of life of a patient with Down disease and Alzheimer degeneration. Taken together
with quantitative histopathologic findings, the electrophysiologic alterations are interpreted
in terms of recent evidence from an experimental animal model of dementia. Neurons with
neurofibrillary degeneration become electrically inactive and contribute to the loss of voltage …