Selective breeding for alcohol preference and associated responses
TK Li, L Lumeng, DP Doolittle - Behavior genetics, 1993 - Springer
TK Li, L Lumeng, DP Doolittle
Behavior genetics, 1993•SpringerSelective breedng for high and low alcohol-drinking preference has produced rat lines
useful for studying the nature of excessive alcohol-seeking behavior. Compared with the
alcohol-nonpreferring line, the preferring animals exhibit heightened responsivity to the low-
dose activating effects of ethanol as well as enhanced capacity for developing tolerance to
the aversive, behaviorally impairing effects of ethanol. The preferring animals exhibit lower
brain serotonin and dopamine neurotransmitter activity as well as differences in other …
useful for studying the nature of excessive alcohol-seeking behavior. Compared with the
alcohol-nonpreferring line, the preferring animals exhibit heightened responsivity to the low-
dose activating effects of ethanol as well as enhanced capacity for developing tolerance to
the aversive, behaviorally impairing effects of ethanol. The preferring animals exhibit lower
brain serotonin and dopamine neurotransmitter activity as well as differences in other …
Abstract
Selective breedng for high and low alcohol-drinking preference has produced rat lines useful for studying the nature of excessive alcohol-seeking behavior. Compared with the alcohol-nonpreferring line, the preferring animals exhibit heightened responsivity to the low-dose activating effects of ethanol as well as enhanced capacity for developing tolerance to the aversive, behaviorally impairing effects of ethanol. The preferring animals exhibit lower brain serotonin and dopamine neurotransmitter activity as well as differences in other neurotransmitter neuromodulator systems, compared with the alcoholnonpreferring animals.
Springer