Human apolipoprotein E is the major apolipoprotein expressed in the brain and exists as
three isoforms, designated E2, E3, and E4. Although evidence suggests that apolipoprotein
E plays an important role in modifying systemic and brain inflammatory responses, there is
little data investigating apoE isoform-specific effects in vivo. In this study, we compared the
inflammatory responses of targeted-replacement mice expressing the human APOE3 and
APOE4 genes after intravenous administration of lipopolysaccharide. Animals expressing …