Soluble interleukin-6 receptor (sIL-6R) in cerebrospinal fluid of patients with inflammatory and non inflammatory neurological diseases
M Michalopoulou, C Nikolaou, A Tavernarakis… - Immunology letters, 2004 - Elsevier
IL-6 acts on target cells via the ligand-binding protein interleukin-6 receptor (IL-6R) and the
affinity-converting and signal-transducing glycoprotein 130 (gp130). Soluble interleukin-6
receptor (sIL-6R) has an agonistic role because the soluble complex (IL-6/sIL-6R) can
activate cells that do not express IL-6R and an antagonistic role as it enhances the inhibitory
activity of sgp130. Soluble forms of both receptors, sIL-6R and sgp130, regulate the action of
IL-6. sIL-6R was measured by a sensitive enzyme-linked immunosorbent assay in paired …
affinity-converting and signal-transducing glycoprotein 130 (gp130). Soluble interleukin-6
receptor (sIL-6R) has an agonistic role because the soluble complex (IL-6/sIL-6R) can
activate cells that do not express IL-6R and an antagonistic role as it enhances the inhibitory
activity of sgp130. Soluble forms of both receptors, sIL-6R and sgp130, regulate the action of
IL-6. sIL-6R was measured by a sensitive enzyme-linked immunosorbent assay in paired …