Inducible nitric oxide synthase in chronic active multiple sclerosis plaques: distribution, cellular expression and association with myelin damage
KE Hill, LV Zollinger, HE Watt, NG Carlson… - Journal of …, 2004 - Elsevier
Inducible nitric oxide synthase (iNOS) is an enzyme that produces nitric oxide (NO) and is
thought to contribute to the pathogenesis of multiple sclerosis (MS). The extent of iNOS
expression was examined using laser scanning confocal microscopy of 13 chronic active
plaques from seven MS patients displaying both acute demyelination and active
inflammation. iNOS expression in these plaques was substantial and diverse in cellular
distribution. Expression of iNOS was observed in ependymal cells located in periventricular …
thought to contribute to the pathogenesis of multiple sclerosis (MS). The extent of iNOS
expression was examined using laser scanning confocal microscopy of 13 chronic active
plaques from seven MS patients displaying both acute demyelination and active
inflammation. iNOS expression in these plaques was substantial and diverse in cellular
distribution. Expression of iNOS was observed in ependymal cells located in periventricular …